By Tony J. C. Harris (auth.), Tony Harris (eds.)
Cell–cell adhesion is prime for the advance and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the easiest understood cell-cell adhesion complexes. during this quantity, a bunch of across the world famous specialists reports AJ biology over a variety of association; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and total animal improvement. AJs have additionally been a vital part of animal evolution, and play valuable roles in melanoma improvement, pathogen an infection and different ailments. This e-book addresses significant questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins engage to collect AJs and mediate adhesion?
• How do AJs interface with different mobile equipment to couple adhesion with the entire mobilephone?
• How do AJs have an effect on phone behaviour and multicellular improvement?
• How can irregular AJ job bring about disease?
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Extra resources for Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease
The arm domain is slightly twisted and this results in consecutively ordered H3 helices forming a concave groove that is 95 Å long and 20 Å wide (Huber et al. 1997). Multiple basic residues from H3 and the first turn of H1 in arm repeats 1–10 give this groove a large positively charged surface critical for interacting with various ligands, including E-cadherin (Huber and Weis 2001). Besides the basic arm groove, the arm domain has an exposed hydrophobic pocket on repeat 1, which is also involved in ligand binding.
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507 Greenwood MD, Marsden MD, Cowley CM, Sahota VK, Buxton RS (1997) Exon-intron organization of the human type 2 desmocollin gene (DSC2): desmocollin gene structure is closer to “classical” cadherins than to desmogleins. Genomics 44:330–335. 4894 Grimson MJ, Coates JC, Reynolds JP, Shipman M, Blanton RL, Harwood AJ (2000) Adherens junctions and β-catenin-mediated cell signalling in a non-metazoan organism. 1038/35047099 Haruta T, Warrior R, Yonemura S, Oda H. (2010) The proximal half of the Drosophila E-cadherin extracellular region is dispensable for many cadherin-dependent events but required for ventral furrow formation.